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M94A2952.TXT
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1994-10-25
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Document 2952
DOCN M94A2952
TI Experience of two years in therapy of AIDS hypersecretory diarrhea with
octreotide.
DT 9412
AU Miranda-Ruiz R; Feregrino-Goyos M; Alvarado Diez R; Castanon GJ;
Gallegos-Perez H; Eid-Lidt G; Hospital Especialidades del Centro Medico
siglo XXI del IMSS,; Mexico D.F., Mexico.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):187 (abstract no. PB0177). Unique
Identifier : AIDSLINE ICA10/94369623
AB OBJECTIVES: Evaluation of the use of octreotide(analog to long range
action synthetic somatostatin) in therapy of severe and chronic
hypersecretory diarrhea from AIDS (with more than 10 daily evacuations
and 2 to 7 liters of daily volume of feces)compared to a similar control
group. METHODS: 90 HIV patients were studied.Group I of 20 patients
received conventional antibiotics therapy against opportunistcs germs
and nutritional support, compared to 70 patients of the Group II that
received additionally 200 mcg sc of OCTREOTIDE, every 6 hrs, during a
minimum period of one month. Ten patients received octreotide
intermitently until 15 months. Age, CD4, weight previous loss, volume
and number of evacuations,coprocultures, sprecial coproparasitoscopics
and rectal byopsies were evaluated.Response of the diarrhea and
microbiological and nutritional response were also evaluated.
Statistical analysis with chi 2 andT Students. RESULTS: Ages were 32
aqnd 35 (pNS). CD4 were 54 and 48 (pNS), previous weight loss 18.4% and
19.2% (pNS); with found microorganisms in both groups:Cryptosporidium,
cytomegsalovirus, isospora belli, E.histolytica, Giardia lamblia,
candida, salmonella ascaris and others.Diarrhea severity was similar in
both groups. After one month of treatment, diarrhea was under control in
20% of Group I and 70% of Group II (p < 0.01).Increase of body weight
was observed only in Group II with Medium of 6% in a month(p < 0.02). No
side effects were observed withthe use of octreotide during long
treatment periods. 20% of the patients showed recurrence of diarrhea
after suspension of octreotide's treatment and we have to rebegining
octreotide intermitently. 20 to 30% of the patients never responded to
octreotide treatment. The exclusion of cryptosporidium could only be
diminished in group II. CONCLUSIONS: Octreotide can control up to 70% of
hypersecretory diarrhea of AIDS.
DE Acquired Immunodeficiency Syndrome/*DRUG THERAPY Adult
Antibiotics/THERAPEUTIC USE AIDS-Related Opportunistic Infections/DRUG
THERAPY Combined Modality Therapy Comparative Study Diarrhea/*DRUG
THERAPY Female Human Male Octreotide/*THERAPEUTIC USE MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).